Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA. steve.estus@uky.edu. Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA. Department of Biostatistics and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA. , Prides Crossing, MA, 01965, USA.